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| Tumor necrosis factor-beta ： ウィキペディア英語版 |
Lymphotoxin alpha
Lymphotoxin-alpha (LT-alpha) or Tumor necrosis factor-beta (TNF-β) is a protein that in humans is encoded by the ''LTA'' gene.
== Function ==
Lymphotoxin alpha, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. LTA is highly inducible, secreted, and exists as homotrimeric molecule. LTA forms heterotrimers with lymphotoxin-beta, which anchors lymphotoxin-alpha to the cell surface. LTA mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. LTA is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4049 )〕
In LTα knockout mice, all Peyer's patches and lymph nodes will fail to develop indicating LTα's importance in immunological development.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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